J Educ Health Promot. Early research shows that taking evening primrose, 3 grams per day in adults or 2 grams per day in children, does not improve symptoms of ichthyosis. Massil H, Brush M, Manku M, and et al. View abstract. Ann Allergy 1989;62(6):534-537. Hanna K, Day A O'Neill S Patterson C Lyons-Wall P. Does scientific evidence support the use of non-prescription supplements for treatment of acute menopausal symptoms such as hot flushes? It may also influence immune function, affecting your body's ability to fight pathogens and infections. Oral essential fatty acid supplementation in atopic dermatitis: a meta-analysis of placebo-controlled trials (Structured abstract). Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with EVENING PRIMROSE OIL. Drug companies' evidence to justify advertising. The potential for dietary supplements to reduce premenstrual syndrome (PMS) symptoms. BMJ 2003;327:1385. Premenstrual syndrome (PMS). Treatment of atopic eczema with evening primrose oil. Arzneimittelforschung. According to the same source, EPO may cause labor abnormalities. Jaszewska, E., Kosmider, A., Kiss, A. K., and Naruszewicz, M. Oenothera paradoxa defatted seeds extract containing pentagalloylglucose and procyanidins potentiates the cytotoxicity of vincristine. Effects of herbal components on cDNA-expressed cytochrome P450 enzyme catalytic activity. Simpson, L. O. Kilic MO, Sen M, Icen D. The comparison of evening primrose oil, fructus agni casti, and reassurance in the treatment of mastalgia. Menendez JA, del Mar Barbacid M, Montero S, et al. 2020;34(10):2628-2638. All information will be used in a manner consistent with the WebMD, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Coronavirus in Context: Interviews With Experts, Sign Up to Receive Our Free Coroanvirus Newsletter, Attention deficit-hyperactivity disorder (ADHD). Breast 2007;16(5):503-512. Clinical benefits of n-3 PUFA and gamma-Linolenic acid in patients with rheumatoid arthritis. An integrative medicine approach to premenstrual syndrome. Biagi, P. L., Bordoni, A., Masi, M., Ricci, G., Fanelli, C., Patrizi, A., and Ceccolini, E. A long-term study on the use of evening primrose oil (Efamol) in atopic children. 2012;3, Centre for Reviews and Dissemination. Ty-Torredes, K. A. Prog Lipid Res 1986;25:335-40. II. 2010;50(5):e106-e115. Research evaluating evening primrose for schizophrenia shows conflicting results. Did you or will you purchase this product in-store or online? Supplement manufacturers claim that it may reduce fatigue, clear acne, promote weight loss and improve asthma symptoms. A prospective, double-blind, placebo-controlled multicentre clinical trial. Clinical experience of drug treatments for mastalgia. A double-blind placebo controlled trial of Efamol Marine on skin and joint symptoms of psoriatic arthritis. Pharmaceutical J 1988;723-725. Proc.2nd International Symposium on Premenstrual, Postpartum and Menopausal Mood Disorders 1987;abstract 44. These symptoms are commonly referred to as PMS, or premenstrual syndrome. Placebo-controlled trial of essential fatty acid supplementation in atopic dermatitis. View abstract. View abstract. This popular home remedy can interact with common drugs — from aspirin to blood thinners — and cause adverse reactions. For example, evening primrose oil should not be used along with Prozac, Zoloft, Celexa and other selective serotonin reuptake inhibitors (SSRIs). 1998;98(3):285-292. It's also marketed for its ability to relieve the pain and discomfort associated with arthritic disorders, eczema, liver cancer and other ailments. View abstract. As the Food and Drug Administration points out, supplements are not intended to prevent, diagnose or treat diseases. Martens-Lobenhoffer, J. and Meyer, F. P. Pharmacokinetic data of gamma-linolenic acid in healthy volunteers after the administration of evening primrose oil (Epogam). This product has minimal side effects when used in small doses. Effect of dietary supplementation with linoleic and gammalinolenic acids on the pressor response to angiotensin II--possible role in pregnancy induced hypertension? Clin Ter. Side Effects of Evening Primrose Oil for Menopause. View abstract. Liu, H. and Zhou, J. F. [Xianbai buyang Huanwu decoction used for treating hypertension with kidney qi deficiency and blood stasis]. Proc Nutr Soc Aust 1985;10:196. Although these findings are promising, more research is needed to validate them. View abstract. Dietary supplements and herbal remedies for premenstrual syndrome (PMS): a systematic research review of the evidence for their efficacy (Structured abstract). Effect of oral gamolenic acid from evening primrose oil on menopausal flushing (abstract). Efficacy of self-help and alternative treatments of premenstrual syndrome (Structured abstract). Mr. Picincu is a regular contributor to these platforms where she either provides health-related content or coaching to those who are interested in achieving a balanced lifestyle. What works for you may not be the best for another. North American Menopause Society. Tanzan Health Res Bull 2007;9(3):196-201. Phytother.Res. Am J Clin Nutr 2000;71:386S-392S. View abstract. Evening Primrose Oil Side Effects In studies, patients taking evening primrose oil have reported only minor side effects like headaches, nausea, upset stomach and loose stool [source: MedicineNet ]. Evening primrose oil may also contribute to seizures in people with epilepsy or schizophrenia, notes the Mayo Clinic. 2010;24(3):238-245. Cameron, M., Gagnier, J. J., and Chrubasik, S. Herbal therapy for treating rheumatoid arthritis. A trial of evening primrose oil in the treatment of chronic schizophrenia. View abstract. Dietary supplement interactions with antiretrovirals: a systematic review. Phytother Res. Before using Evening Primrose Oil, inform your doctor about your current list of medications, over the counter products (e.g. View abstract. Evening primrose oil or other omega-6 fatty acids should be avoided by anyone who suffers a seizure disorder or bleeding problems. View abstract. J Orhtomolecular Psych 1983;12:302-304. Hunter JO and Wilson AJ. In one study, infants fed this formula had better eyesight than infants fed regular formula, but not better than those who were breastfed. 2017 Mar 25;9(4). 2012;19(9):995-999. 2012;7(2):273-280. Hounsom, L., Horrobin, D. F., Tritschler, H., Corder, R., and Tomlinson, D. R. A lipoic acid-gamma linolenic acid conjugate is effective against multiple indices of experimental diabetic neuropathy. Quiz: What Do You Know About Vitamin B12 Deficiency? Centre for Reviews and Dissemination. Evening primrose oil: a panacea? 2009;25(3):166-174. . View abstract. Horrobin, D. F. Essential fatty acid and prostaglandin metabolism in Sjogren's syndrome, systemic sclerosis and rheumatoid arthritis. View abstract. According to … Horrobin, D. F. and Morse, P. F. Evening primrose oil and atopic eczema. View abstract. This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. Semin Dial 2002;15:53-9.. View abstract. Liver cancer. Rock, E. and DeMichele, A. Nutritional approaches to late toxicities of adjuvant chemotherapy in breast cancer survivors. Horrobin, D. F. Effects of evening primrose oil in rheumatoid arthritis. Carter, J. and Verhoef, M. J. Efficacy of self-help and alternative treatments of premenstrual syndrome. Treatment of Sjogren's syndrome with essential fatty acids, pyridoxine and vitamin C. Prostaglandins Leukot Med 1982;8:403-8. Prostaglandins Leukot.Essent.Fatty Acids 1999;60(3):199-208. Humphreys F, Symons J, Brown H, and et al. A motor skill disorder marked by clumsiness (developmental coordination disorder or DCD). That being said, it can cause some side effects, like abdominal pain, nausea, and diarrhea. Horner NK, Lampe JW. The Medicines Control Agency (MCA), Epogam and Efamast (gamolenic acid) - withdrawal of marketing authorizations. The effects of vitamin D and evening primrose oil co-supplementation on lipid profiles and biomarkers of oxidative stress in vitamin D-deficient women with polycystic ovary syndrome: a randomized double-blind, placebo-controlled trial. Budeiri D, Li Wan Po A, Dornan JC. Childbirth. 1992;46(3):161-164. Leaf Group Ltd. The lipids that matter from infant nutrition to insulin resistance. Douglas, S. Premenstrual syndrome. 2009;12(5):394-401. Taking evening primrose oil doesn't seem to reduce blood pressure in women with pre-eclampsia. When taken by mouth, it can sometimes cause mild side effects including upset stomach, nausea, diarrhea, and headache. Brzeski M, Madhok R, and Capell HA. Scan J Rheumatol 1986;15:103-8. Water warts. In fact, its side effects may outweigh any potential benefits. Meigel, W., Dettke, T., Meigel, E. M., and Lenze, U. View abstract. Evening primrose oil and marine oil in the treatment of psoriasis. View abstract. Evening primrose oil may increase the effects of the HIV medicine lopinavir. There are certain medical conditions for which evening primrose oil may pose serious health risks. Farzaneh F, Fatehi S, Sohrabi MR, Alizadeh K. The effect of oral evening primrose oil on menopausal hot flashes: a randomized clinical trial. Sharma N, Gupta A, Jha PK, Rajput P. Mastalgia cured! View abstract. Inflamm.Bowel.Dis 2002;8(3):174-179. Studies show that it may also pose risks during pregancy or … 1999. Joy, C. B., Mumby-Croft, R., and Joy, L. A. Polyunsaturated fatty acid (fish or evening primrose oil) for schizophrenia. Several small studies show that taking 15-20 mL or 4-6 grams of evening primrose daily for up to 16 weeks doesn't improve asthma symptoms. Cheema, D., Coomarasamy, A., and El Toukhy, T. Non-hormonal therapy of post-menopausal vasomotor symptoms: a structured evidence-based review. Phytother Res 2012;26:265-272. View abstract. 8-8-2005;226(1):17-25. J R.Soc Med 1992;85(1):12-15. Poisson J, Germain-Bellenger S, Engler M, and et al. 43 years experience Pathology. Effects of gamma-linolenic acid and oleic acid on paclitaxel cytotoxicity in human breast cancer cells. Kwon HS, Lee JH, Kim GM, Choi EH, Bae JM. Horrobin, D. F. The importance of gamma-linolenic acid and prostaglandin E1 in human nutrition and medicine. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.© Therapeutic Research Faculty . Disorders affecting bile flow in the liver. View abstract. Asthma. The Cochrane review notes that EPO may not be safe in the long run. Lindmark L and Clough P. A 5-month open study with long-chain polyunsaturated fatty acids in dyslexia. Hum Psychopharmacol 1988;3:57-61. View abstract. Takwale A, Tan E, Agarwal S, et al. Oenothera (Evening primrose oil, Fever plant, Sun drops) is an herbal supplement used for its anti-inflammatory and pain-relieving effects. View abstract. This medication contains evening primrose oil. Journal of Dermatological Treatment 1993;4:33-36. Evening primrose oil and premenstrual syndrome. Early research shows that taking 4.8 grams of evening primrose per day for 12 weeks does not add to the weight loss achieved with a reduced calorie diet in obese women. J Psychosom.Obstet.Gynaecol. Am.J.Obstet.Gynecol. View abstract. Int J STD AIDS. Namaka, M., Crook, A., Doupe, A., Kler, K., Vasconcelos, M., Klowak, M., Gong, Y., Wojewnik-Smith, A., and Melanson, M. Examining the evidence: complementary adjunctive therapies for multiple sclerosis. Br Med J 1955;11:1041-1048. Evaluation of efficacy and tolerability of a fixed combination of dry extracts of thyme herb and primrose root in adults suffering from acute bronchitis with productive cough. She holds a BA in Psychology and a BA in Marketing and International Business. Additionally, there is a risk of allergic reactions, warns the European Medicines Agency. Jalloh MA, Gregory PJ, Hein D, et al. Evening primrose oil for atopic dermatitis. Does supplementation of formula with evening primrose and fish oils augment long chain polyunsaturated fatty acid status of low birthweight infants to that of breast-fed counterparts? Prostaglandins Leukot.Essent.Fatty Acids 1993;49(4):809-814. View abstract. View abstract. Vitamin E and evening primrose oil for management of cyclical mastalgia: a randomized pilot study. J.Atten.Disord. Br J Surg 1981;68:801. 1986;15(1):114-115. 1987;62 Suppl 1:100-103. J Nurse Midwifery 1999;44:320-4. Evening Primrose Oil Side Effects. 1994;4(598):603. Horrobin, D. F. Multiple sclerosis: the rational basis for treatment with colchicine and evening primrose oil. Arzneimittelforschung 2006;56(8):574-581. Essential fatty acid deficiency in erythrocyte membranes from chronic schizophrenic patients, and the clinical effects of dietary supplementation. Tomczyk, M., Zovko-Koncic, M., and Chrostek, L. Phytotherapy of alcoholism. View abstract. Vaddadi KS. It's not clear if this benefit results from evening primrose or fish oil. Menopause. . View abstract. J Nutr Med 1991;2:259-264. View abstract. High quality research shows that evening primrose is no more effective than a placebo (sugar pill) for reducing breast pain. Possible side effects of evening primrose oil for weight loss. Goyal, A. and Mansel, R. E. A randomized multicenter study of gamolenic acid (Efamast) with and without antioxidant vitamins and minerals in the management of mastalgia. Anstey A, Quigley M, Wilkinson JD. View abstract. Use evening primrose oil in small doses for short periods. Improvement seems to take place within 1-2 weeks of starting treatment. View abstract. Oral omega-6 essential fatty acid treatment in contact lens associated dry eye. McKendry RJ. View abstract. 2010;89(4):427-428. van der Merwe, C. F. Booyens J. A learning disorder marked by difficulty reading (dyslexia). Manku, M. S., Horrobin, D. F., Morse, N., Kyte, V., Jenkins, K., Wright, S., and Burton, J. L. Reduced levels of prostaglandin precursors in the blood of atopic patients: defective delta-6-desaturase function as a biochemical basis for atopy. 1988;8:469-71, 452-3. Cancer Lett. Halat, K. M. and Dennehy, C. E. Botanicals and dietary supplements in diabetic peripheral neuropathy. J Fam.Pract. Taking evening primrose oil along with medications that also slow clotting might increase the chances of bruising and bleeding. J Fam.Pract. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. 1998;36(7):363-366. Herbs for mental illness: effectiveness and interaction with conventional medicines. View abstract. Lets take a look at other precautions to be mindful of when using evening primrose oil. Side effects of evening primrose oil Short-term use of EPO has been shown to be safe. More than 90 percent of women experience bloating, mood swings, irritability, aches and other symptoms before and during their periods. Ring, J. and Kleinheinz, A. View abstract. Jill Corleone is a registered dietitian with more than 20 years of experience. Khorshidi M, Zarezadeh M, Moradi Moghaddam O, et al. View abstract. Clin Exp Dermatol. View abstract. Obstet Gynecol 1993;81(1):93-98. Most of the time it happens because the dose is too high. Where did you or where do you plan to purchase this product? Abstracts from the International Symposium on Gamma Linolenic Acid, American Oil Chemists Society, Health and Nutrition Division Annual Conference, San Diego, CA, 2000. Copyright © Gastroenterology 1993;105(1):267-271. View abstract. The effects of essential fatty acid supplementation by Efamol in hyperactive children. Pediatr.Allergy Immunol. Med Hypotheses 2000;54(1):72-74. diagnosis or treatment. Pruthi S, Wahner-Roedler DL, Torkelson CJ, Cha SS, Thicke LS, Hazelton JH, and Bauer BA. Bordoni A, Biagi PL, Masi M, et al. 1993;27(12):1475-1477. Zhong Xi Yi Jie He Za Zhi 1991;11:20-2, 4. A single-blind, randomized, bi-centric clinical trial. Sinn N, Bryan J. Lancet 1-28-1995;345(8944):260-261. J Perinat.Neonatal Nurs. Herbs, menopause, and dialysis. Prostaglandins Leukot Essent Fatty Acids 1994;51:311-6. View abstract. As mentioned earlier, this home remedy might increase bleeding. 8-30-1985;54(2):490-494. Effect of primrose oil on serum lipids and blood pressure in hyperlipidemic subjects. Menendez JA, Colomer R, Lupu R. Omega-6 polyunsaturated fatty acid gamma-linolenic acid (18:3n-6) is a selective estrogen-response modulator in human breast cancer cells: gamma-Linolenic acid antagonizes estrogen receptor-dependent transcriptional activity, transcriptionally represses estrogen receptor expression and synergistically enhances tamoxifen and ICI 182,780 (Faslodex) efficacy in human breast cancer cells. Clinical Uses of Essential Fatty Acids . Ther Adv Psychopharmacol. View abstract. 2008;57(8):542-544. View abstract. Essential fatty acid supplementation in chronic hepatitis B. Aliment Pharmacol Ther 1996;10(4):665-668. Side Effects of Evening Primrose Oil. Med Monatsschr.Pharm. View abstract. Lancet 1993;341:1557-60. View abstract. Vitamin D and evening primrose oil administration improve glycemia and lipid profiles in women with gestational diabetes. (Accessed 2 June 2003). Br.J Dermatol. Preece PE, Hanslip JI Gilbert L. Evening primrose oil (Efamol) for mastalgia. View abstract. Furse RK, Rossetti RG, Seiler CM, Zurier RB. ), allergies, pre-existing diseases, and current health conditions (e.g. Side-Effects & Allergies of Evening Primrose Oil Evening primrose oil has shown to be increasing the chances of bruising and bleeding, which might worsen in case of bleeding disorder and surgeries. Neurol.Res 2008;30(7):710-719. Moodley J and Norman RJ. Online ahead of print. Holist.Nurs.Pract. Prostaglandins Med 1981;6(4):375-379. Zou L, Harkey MR, and Henderson GL. Cheung KL. Life Sci 8-16-2002;71(13):1579-1589. New York: Wiley-Liss;1990. View abstract. View abstract. Veselinovic M, Vasiljevic D, Vucic V, et al. View abstract. A., Chasuk, R., and Kendall, S. Which complementary therapies can help patients with PMS? Some research shows that taking 4 grams daily for 3 months, or 3 grams daily from day 15 until the end of the menstrual cycle for 4 cycles, improves self-reported symptoms. Chalmers RJ and Shuster S. Evening primrose seed oil in ichthyosis vulgaris. Pellegrina, C. D., Padovani, G., Mainente, F., Zoccatelli, G., Bissoli, G., Mosconi, S., Veneri, G., Peruffo, A., Andrighetto, G., Rizzi, C., and Chignola, R. Anti-tumour potential of a gallic acid-containing phenolic fraction from Oenothera biennis. Effect of evening primrose oil supplementation on lipid profile: a systematic review and meta-analysis of randomized clinical trials. Tang W, Song YF He ZM. Efficacy and tolerability of borage oil in adults and children with atopic eczema: randomised, double blind, placebo controlled, parallel group trial. https://www.mca.gov.uk/whatsnew/epogam.htm. (Oxford) 2003;42(5):652-659. View abstract. Prostaglandins Leukotrienes Essential Fatty Acids 2007;77:101-3. View abstract. CONDITIONS OF USE AND IMPORTANT INFORMATION: Woltil, H. A., van Beusekom, C. M., Schaafsma, A., Okken, A., and Muskiet, F. A. Evidence-based treatment in family practice. Peet M, Laugharne JD, Mellor J, and Ramchand CN. The effect of oral evening primrose oil on bishop score and cervical length amongst term gravidas. When taken in appropriate amounts short term, oral use of evening primrose oil is most likely safe.Evening primrose oil can cause: 1. As with all dietary supplements, talk with your health care provider before taking evening primrose oil if you are taking any kind of medicine. View abstract. 2001;44(4):853-863. Haslett C, Douglas JG, Chalmers SR, Weighhill A, and Munro JF. Masi M, and Hughes LE to angiotensin II in rats with Raynaud )..., Safranek, S. and Burton, J. C. [ schizophrenia and prostaglandins specific health circumstances ferulic. 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